97. Another very important document of the Second Vatican Council in the corpus of the Church's social doctrine is the Declaration Dignitatis Humanae[179], in which the right to religious freedom is clearly proclaimed. The document presents the theme in two chapters. The first, of a general character, affirms that religious freedom is based on the dignity of the human person and that it must be sanctioned as a civil right in the legal order of society. The second chapter deals with the theme in the light of Revelation and clarifies its pastoral implications, pointing out that it is a right that concerns not only people as individuals but also the different communities of people.
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427. In order to prevent or attenuate possible conflicts between the Church and the political community, the juridical experience of the Church and the State have variously defined stable forms of contact and suitable instruments for guaranteeing harmonious relations. This experience is an essential reference point for all cases in which the State has the presumption to invade the Church's area of action, impairing the freedom of her activity to the point of openly persecuting her or, vice versa, for cases in which church organizations do not act properly with respect to the State.
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Abstract:Although surgical resection is available as a potentially curative therapy for hepatocellular carcinoma (HCC), high recurrence of HCC after surgery remains a serious obstacle for long-term patient survival. Therefore, the discovery of valuable prognostic biomarkers for HCC recurrence is urgently needed. Pre-S2 mutant is a mutant form of hepatitis B virus (HBV) large surface protein which is expressed from the HBV surface gene harboring deletion mutations spanning the pre-S2 gene segment. Pre-S2 mutant-positive HCC patients have been regarded as a high-risk population of HCC recurrence after resection surgery and display increased immune checkpoint programmed death ligand 1 (PD-L1) expression and pro-tumor regulatory T cells (Tregs) infiltration in tumor tissues. In this study, the association of higher levels of PD-L1 expression and Tregs infiltration in tumor tissues with post-operative HCC recurrence in pre-S2 mutant-positive HCC patients was evaluated. We found that patients with pre-S2 mutant in combination with higher levels of PD-L1 expression and Tregs infiltration in tumor tissues were independently associated with a higher risk of HCC recurrence (hazard ratio, 4.109; p value = 0.0011) and poorer recurrence-free survival (median, 8.2 versus 18.0 months; p value = 0.0004) than those of patients with either one or two of these three biomarkers. Furthermore, a combination of pre-S2 mutant, intra-tumoral PD-L1 expression, and tumor-infiltrating Tregs exhibited superior performance in identifying patients at a higher risk of HCC recurrence (area under the receiver operating characteristic curve, 0.8400). Collectively, this study suggests that higher levels of PD-L1 expression and Tregs infiltration in tumor tissues predicted a higher risk of HCC recurrence in pre-S2 mutant-positive HCC patients after curative surgical resection.Keywords: hepatocellular carcinoma; recurrence; pre-S2 mutant; hepatitis B virus; curative surgical resection; programmed death ligand 1; regulatory T cells
Both Camus and Hemingway quote Dolorès Ibarruri, the Spanish communist deputyduring the Civil War, better known as La Pasionaria, who said that "It's better to die on yourfeet than live on your knees" (Hr 425).[14] These words stress thevalue of rebellion and the dignity of theindividual, because those who are willing todie for the general good affirm a value thattranscends them as individuals. However, in"La Pensée de midi," Camus draws the linebetween self-sacrifice and the arrogance ofpower, which, in killing, denies the freedomof others and nullifies the logic of rebellion(Hr 687-89). Murder destroys the collective cogito and the bond of solidarity that validateshistory and life: "when rebellion foments destruction, it is illogical. As long as it stresses theunity of the human condition, it is a force for life, not death" (Hr 688). The logic ofrebellion, says Camus, is the logic of creation, not destruction.
However, as Camus points out, despite Spartacus's discipline, the revolt failed becauseinstead of attacking Rome immediately he retreated to Sicily, where he was eventuallydefeated by Crassus. Because Spartacus crucified one Roman citizen, Crassus crucifiedthousands of defeated slaves. Camus's point is that Spartacus's revolt contributed nothingnew to Roman society and that retribution and bloodshed, the hallmark of all revolutions,did not advance the cause of human solidarity. Spartacus was killed by mercenary slaveswho, in killing him, were also killing their own freedom. Camus concludes that Spartacus'srevolt failed because the rebels were repeating the mistakes of all previous servile revoltsin which the slaves were freed and their masters enslaved (Hr 518-20).
When Angioletto had been assured of the nesting of his mate, he dressedhimself point-device and went to Court to deliver his credentials. Hefound the lady upon whom so much depended, at the Schifanoia. MadamaLionella d'Este, wife of the Count Guarino Guarini, was afresh-coloured, lusty young woman of three and twenty, not at all inlove with her husband, but very much in love with love. The Captain ofLances had said truly when he shrugged her off as no beauty.Large-limbed she was, the shape of a boy, with a long mouth and smalleyes, full-lipped, big in foot and hand. Yet she was a very merry soul,frank if not free in her speech and gesture, and though liable to burstsof angry temper, for the most part as innocent of malice as a tiger cub.If you remember her an Este, you will forgive her much, excuse hereverything, and rather like her.
"Hey, hey!" he cried, as there was a prodigious scuffling up thechimney. "Now he strangles, now he strangles!" A shower of soot camedown. Beppo flacked about the room; then two heavy objects fell. Beppocrept up. "Mary [Pg 311]Virgin, he's killing birds," he said, in an awedwhisper, and picked up two owls with wagging heads. The recesses of thechimney were still very lively. "Eh, there he is again," said the oldsweep. "What now?" Down came a rat, squeaking for its life, then threein succession, very silent because their necks were wrung. "This isbetter than a cat any day of the seven," said Sor Beppo. "What a diamondof a poet! He should be crowned with laurel-twigs if I were Duke Borsoin all his glory. Being but Beppo the sweep, he shall be free of mymystery the moment he's free of my chimney-stack." 2ff7e9595c
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